Sequence variability is correlated with weak immunogenicity in Streptococcus pyogenes M protein
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چکیده
منابع مشابه
Sequence variability is correlated with weak immunogenicity in Streptococcus pyogenes M protein
The M protein of Streptococcus pyogenes, a major bacterial virulence factor, has an amino-terminal hypervariable region (HVR) that is a target for type-specific protective antibodies. Intriguingly, the HVR elicits a weak antibody response, indicating that it escapes host immunity by two mechanisms, sequence variability and weak immunogenicity. However, the properties influencing the immunogenic...
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ژورنال
عنوان ژورنال: MicrobiologyOpen
سال: 2015
ISSN: 2045-8827,2045-8827
DOI: 10.1002/mbo3.278